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Teratogenic drugs Wikipedia

From Wikipedia, the free encyclopedia The main article for this category is Teratology. Teratogens are substances that may cause birth defects via a toxic effect on an embryo or foetus. Wikimedia Commons has media related to Teratogens From Simple English Wikipedia, the free encyclopedia This symbol shows that a substance is damaging to human health. This includes substances that cause birth defects. A teratogen is a material that can cause congenital defects MDMA is a moderately teratogenic drug (i.e., it is toxic to the fetus). In utero exposure to MDMA is associated with a neuro- and cardiotoxicity and impaired motor functioning. Motor delays may be temporary during infancy or long-term. The severity of these developmental delays increases with heavier MDMA use Thalidomide, sold under the brand names Contergan and Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. While it has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus

Category:Teratogens - Wikipedi

  1. Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is rarely used. In the past, it was widely used for a variety of indications, including pregnancy support for women with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency in women, treatment of prostate cancer in men and breast.
  2. Lamotrigine, sold as the brand name Lamictal among others, is an anticonvulsant medication used to treat epilepsy and to delay or prevent the recurrence of depressive episodes in bipolar disorder. For epilepsy, this includes focal seizures, tonic-clonic seizures, and seizures in Lennox-Gastaut syndrome. In bipolar disorder, lamotrigine has not been shown to reliably treat acute depression; but.
  3. e their teratogenicity to

The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy.It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk.. Every drug has specific information listed in its product literature. The British National Formulary used to provide a table. Any substance that is taken or administered to cause physiological changes, especially one prescribed by a doctor to treat or prevent a medical condition. Drugs that affect the central nervous system are often addictive. The American Heritage® Student Science Dictionary, Second Edition Teratogens are substances that may produce physical or functional defects in the human embryo or fetus after the pregnant woman is exposed to the substance. Alcohol and cocaine are examples of such substances A teratogenic substance, or teratogen, are chemicals that affects the normal growth and development of a fetus. These abnormalities or malformation can even affect the viability of the pregnancy. It does not only apply to pharmaceutical drugs

teratogenic adjective Referring to a chemical (e.g., thalidomide), physical (e.g., radiation) or other factor capable of causing birth defects. noun An agent with a teratogenic effect; teratogen. Segen's Medical Dictionary. © 2012 Farlex, Inc Privacy & Trust Info Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs

Teratogen - Simple English Wikipedia, the free encyclopedi

Retinoic acid or vitamin A derivatives are extremely teratogenic in humans. Even at very low doses, oral medications such as isotretinoin, used in the treatment of acne, are potent teratogens. The critical period of exposure appears to be from the second to the fifth week of gestation. The most common malformations include craniofacial dysmorphisms, cleft palate, thymic aplasia, and neural tube defects toxic substances are described as teratogenic (literally, monster-producing). The sedative and antiemetic agent thalidomide and the anticonvulsant drug phenytoin are notorious examples of teratogens. Women frequently are advised to avoid all drugs (including nicotine) during pregnancy, unless the medicine is well-tried and essential A summary of 3 studies showed 4 of 14 men taking colchicine developed reversible azoospermia. When tested in mice given 1.25 to 1.5 mg/kg and hamsters given 10 mg/kg, colchicine was shown to be teratogenic. The drug can lower sperm counts and cause sperm defects, affecting the ploidy of sperm and resulting in birth defects drug (drŭg), 1. Therapeutic agent; any substance, other than food, used in the prevention, diagnosis, alleviation, treatment, or cure of disease. For types or classifications of drugs, see the specific name. See also: agent. 2. To administer or take a drug, usually implying an overly large quantity or a narcotic. 3. General term for any substance.

Thalidomide (pronounced /θəˈlɪdəmaɪd/) is a sedative-hypnotic and multiple myeloma medication. The drug is potent teratogen in rabbits and primates including humans: severe birth defects may result if the drug is taken during pregnancy Exposure to drugs during pregnancy has the potential to harm offspring. Teratogenic effects are the most feared adverse outcomes in newborns; however, a wide spectrum of less known, usually reversible and often acute, neonatal adverse events can also occur due to drug intake by mothers during pregnancy, particularly in close proximity to delivery A teratogen is any agent that causes an abnormality following fetal exposure during pregnancy. Teratogens are usually discovered after an increased prevalence of a particular birth defect. For example, in the early 1960's, a drug known as thalidomide was used to treat morning sickness. Exposure of the fetus during this early stage of development resulted in cases of phocomelia, a congenital.

A teratogen is a substance that can cause abnormalities or birth defects in a developing fetus. Common teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, uncontrolled health problems in the birthing parent. Alcohol is a well-known teratogen that can cause harmful. of drugs and have an effect on drug level and fetal drug exposure. There is an association between P-glycoprotein polymorphisms and the risk of fetal birth defects induced by medications during pregnancy.14 Six underlying teratogenic mechanisms are stated to be associated with medication- use. They include folate antagonism, neural crest cel Define teratogenic medication. teratogenic medication synonyms, teratogenic medication pronunciation, teratogenic medication translation, English dictionary definition of teratogenic medication. n. 1. A drug or other substance used to treat disease or injury; a medicine. 2. The act or process of treating a patient with medicine: the response to.. Drugs reaching the embryo during this stage may result in spontaneous abortion, a sublethal gross anatomic defect (true teratogenic effect), covert embryopathy (a permanent subtle metabolic or functional defect that may manifest later in life), or an increased risk of childhood cancer (eg, when the mother is given radioactive iodine to treat.

Teratology (from the Greek τέρᾰς ( genitive τέρᾰτος ), meaning monster, or marvel and λόγος, meaning word, speech) as early as 17th century referred to a discourse on prodigies and marvels, of anything so extraordinary as to seem abnormal. In 19th century, it acquired a meaning closer related to biological deformities, mostly. It is the most widely prescribed teratogenic drug in the USA and Canada. Due to its adverse effect and the necessity for its long term use, most patients show noncompliance and some refuse to take the drug. 37. Mefloquine (MQ) is a potent effective antimalarial drug against Plasmodium Falciparum. It is safe during the second and third trimesters The teratogenic potential of newer AEDs is even less well known, which prevents a rational approach to AED treatment in women of childbearing potential. The European Registry of Antiepileptic Drugs and Pregnancy is a prospective international multicentre study of pregnancies with AEDs. In Germany the project was started in 2001 and so far more.

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Synonyms for teratogenic in Free Thesaurus. Antonyms for teratogenic. 2 words related to teratogen: thalidomide, agent. What are synonyms for teratogenic For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective. X: Contraindicated in pregnancy: Adequate well-controlled or observational studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities or risks. The use. Teratogens. In teratology teratogens are drugs, poisons or toxins that cause congenital disorders and developmental abnormalities, particularly where there is prenatal exposure which can affect prenatal development . A wide range of different chemicals and environmental factors are suspected or are known to be teratogenic in humans and in animals drug 1. any synthetic, semisynthetic, or natural chemical substance used in the treatment, prevention, or diagnosis of disease, or for other medical reasons 2. a chemical substance, esp a narcotic, taken for the pleasant effects it produces 3. drug on the market a commodity available in excess of the demands of the market Collins Discovery Encyclopedia.

medication [med″ĭ-ka´shun] 1. administration of remedies. 2. medicine (def. 1). 3. impregnation with a medicine. nonprescription m's nonprescription drugs. over the counter m's see over the counter medications. transdermal medication medication administered using a self-adhesive, premedicated patch applied to the skin. One side of the patch has an. Medicaid study finds use appears low in teen girls on teratogenic drugs teenage girls on Medicaid who were prescribed teratogenic medications for rheumatic diseases did not receive or fill prescriptions for contraception, and some became pregnant while taking the medication, a study showed teratogenic agent: ( teră-tō-jenik ājĕnt ) Drug, virus, or irradiation that can cause malformation of the fetus. [ terato- + -genic , producing, fr. gennaō , to produce, beget Mnemonics Home | Add a Mnemonic | Whats New | Popular | Top Rated. Mnemonics : Obstetrics : teratogenic drugs. teratogenic drugs. Posted by km2312 on 06-Feb-2012. 8005 people have seen this mnemonic. Print mnemonic | Add comment | Send mnemonic to friend | Add a Mnemonic. 4 people have rated this mnemonic: 5.25/10

teratogen Genetics Any agent, chemical, or factor that causes a physical defect in a developing embryo or fetus; maternal medications with known teratogenic effects include aminopterin-spontaneous abortion, malformations; anticoagulants; anticonvulsants; cytotoxic drugs; mepivacaine-bradycardia, death; methimazole & propylthiouracil-goiter; 131I-destruction of fetal thyroid; ♂ sex. Smoking, alcoholism, taking abortive drugs, exposure to radiation and taking ellicit drugs. What has the author Maurice E Sera written? Maurice E. Sera has written: 'A study of the teratogenic. teratogens: n.pl agents that cause congenital malformations and developmental abnormalities if introduced during gestation Laboratory studies have demonstrated that many chemotherapeutic drugs are teratogenic (can interfere with the development of a fetus), often in more than one animal species. Some classes of drugs are more hazardous than others and, as a group, antineoplastic drugs have been shown in animal studies to be some of the most potent teratogenic.

Thalidomide - Wikipedi

Thalidomide, a drug capable of causing fetal abnormalities (teratogen), has caused greater than ten thousand birth defects worldwide since its introduction to the market as a pharmaceutical agent. Prior to discovering thalidomide's teratogenic effects in the early 1960s, the US Food and Drug Administration (FDA) did not place regulations on drug approval or monitoring as it later did Teratogenic antibiotics Classes of teratogens include radiation, maternal infections, chemicals, and drugs Birth defects are known to occur in 3-5% of all newborns. They can do direct damage to the fetus, causing abnormal development. They can compromise the function of the placenta, often by constricting blood vessels and reducing the. teratogen. ( ˈtɛrətədʒən; tɪˈrætə-) n. (Medicine) any substance, organism, or process that causes malformations in a fetus. Teratogens include certain drugs (such as thalidomide), infections (such as German measles), and ionizing radiation. ˌteratoˈgenic adj. ˌteratoˈgenicist n. ˌteratogeˈnicity n. Collins English Dictionary. Zonegran Description. Zonegran ® (zonisamide) is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The active ingredient is zonisamide, 1,2-benzisoxazole-3-methanesulfonamide. The empirical formula is C 8 H 8 N 2 O 3 S with a molecular weight of 212.23. Zonisamide is a white powder, pKa = 10.2, and is moderately soluble in water (0.80 mg/mL. Diazepam is a benzodiazepine derivative. The chemical name of Diazepam is 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one. It is a colorless to light yellow crystalline compound, insoluble in water. The empirical formula is C 16 H 13 ClN 2 O and the molecular weight is 284.75. The structural formula is as follows: Diazepam is.

adjusting for teratogenic drugs, and investigatingtemporaltrends.A Pvalue oflessthan.05wasconsideredsignifi-cant. RESULTS A total of 837795 live births were in-cludedinthestudycohort,andamong these19960werediagnosedwithama-jorbirthdefect(2.4%)duringthefirst yearoflife.Descriptivecharacteristic teratogen ( plural teratogens ) ( teratology) Any agent or substance which can cause malformation of an embryo or birth defects Noun. 1. teratogen - any agent that interferes with normal embryonic development: alcohol or thalidomide or X-rays or rubella are examples. thalidomide - a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis. agent - an active and efficient cause; capable of producing a. 1962 photo of baby born with an extra appendage connected to the foot caused by the pregnant mother taking the drug. File:Kelsey 01.jpg. FDA inspector Frances Oldham Kelsey receiving an award from President John F. Kennedy in 1962 for blocking use of the drug in the United States. Thalidomide is a sedative-hypnotic, and multiple myeloma medication A fat-soluble vitamin or a mixture of vitamins, especially vitamin A 1 or a mixture of vitamins A 1 and A 2, occurring principally in fish-liver oils, milk, and some yellow and dark green vegetables, and functioning in normal cell growth and development.Vitamin A deficiency can cause damage to epithelial cells, resulting in hardening and roughening of the skin, degeneration of mucous membranes.

Diethylstilbestrol - Wikipedi

If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Retrospective case reviews suggest that, compared with monotherapy, there may be a higher prevalence of teratogenic effects associated with the use of anticonvulsants in. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 July 2021), Cerner Multum™ (updated 1 July 2021), ASHP (updated 30 June. Synonyms for teratogenic medication in Free Thesaurus. Antonyms for teratogenic medication. 20 synonyms for medication: medicine, drug, cure, remedy, prescription. Valproate, linked to increases in both anatomic and behavioral teratogenicity, was less often prescribed, but nevertheless still prescribed in a considerable proportion of patients in the study, which looked at U.S

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Pregnancy category - Wikipedi

Teratogenic drug - definition of teratogenic drug by The

Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs. Drugs that are capable of acting as teratogens include Teratogenic action of the drugs appears after its administration during pregnancy. It is characterized by the disturbed growth processes of fetus that lead to the formation of growth anomalies and malformed neonate. The most dangerous period is the first trimester of pregnancy (2-3 months) during formation of organs and systems.. Prescription drugs and biologic products submitted after June 30, 2015, will use the new format immediately, while labeling for prescription drugs approved on or after June 30, 2001, will be. Teratogens are drugs, chemicals, or even infections that can cause abnormal fetal development. There are billions of potential teratogens, but only a few agents are proven to have teratogenic effects

Illustrated Glossary of Organic Chemistry - Antiemetic

Drug rehabilitation is the process of medical or psychotherapeutic treatment for dependency on psychoactive substances such as alcohol, prescription drugs, and street drugs such as cannabis, cocaine, heroin or amphetamines. The general intent is to enable the patient to confront substance dependence, if present, and cease substance abuse to avoid the psychological, legal, financial, social. Heparin is an anticoagulant that has a short action of about 12 hours. Warfarin is the anticoagulant given for long term treatment. Hope this helps On September 27, 2007, President George W. Bush signed into law the Food and Drug Administration Amendments Act of 2007 (FDAAA), further amending the Food, Drug, and Cosmetic Act.The FDAAA authorizes the Food and Drug Administration (FDA) to require risk evaluation and mitigation strategies (REMS) on medications if necessary to minimize the risks associated with some drugs Other rare side effects of finasteride include gynecomastia, testicular pain, and depression [14]. Side effects are more likely to occur with the typical 5 mg dose used to treat benign prostatic hypertrophy. Although finasteride is teratogenic, the finasteride concentration in semen does not pose a risk to women trying to conceive

Teratogens The Embryo Project Encyclopedi

Teratogenic effects: Pregnancy Category D. Nonteratogenic Effects [edit | edit source] Nonteratogenic Effects: It should be considered that the child born of a mother who is receiving benzodiazepines may be at risk of developing withdrawal symptoms from the drug during the postnatal period. Also, neonatal flaccidity and respiratory problems. teratogenicity ( countable and uncountable, plural teratogenicities ) ( teratology) The capability to cause malformations or defects to an embryo or foetus Drugs (cont.) • Antipsychotic drugs (major tranquilizers) • Phenothiazine & lithium • Suspected teratogenic agents • Antianxiety drugs (minor tranquilizers) • Meprobamate, chlordiazepoxide, • Severe anomalies in 11-12% of offspring where mothers were treated with the above compared to 2.6% of controls • diazepam (valium.

Acne

Vitamin C, also known as ascorbic acid, is a vitamin.It is found in fresh fruits, berries and vegetables.It is one of the water-soluble vitamins.. Vitamin C is important in wound healing. Without enough vitamin C, a person can get a sickness called scurvy.Lack of vitamin C was a serious health problem on long ocean trips where supplies of fresh fruit were quickly used up The current choices for treating female hair loss are quite dismal: Topical 2% Rogaine (minoxidil) is the only FDA-approved treatment. In trying to find other options for women, researchers looked into whether Propecia (finasteride), an effective treatment for hair loss in men, would work for women

A substance that reduces or suppresses inflammation. A substance that inhibits or prevents the proliferation of neoplasms. Originally introduced as a sedative and hypnotic for treatment of morning sickness in 1957, thalidomide was withdrawn from use in the early 1960s after it was shown to produce severe teratogenic effects Cytotoxic drugs have both anti-cancer activity and the potential to damage normal tissue; most cytotoxic drugs are teratogenic. Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. In an increasing number of cases chemotherapy may be combined with radiotherapy or surgery or both as either. An anti-epilectic and anti-carcinogenic drug with toxic and teratogenic properties, which dissolves to valproate in the gut. ChEBI is part of the ELIXIR infrastructure This service is an Elixir Core Data Resource ACE inhibitors have few important interactions with other drugs. Quinapril may reduce the absorption of tetracycline because quinapril (Accupril) contains magnesium which binds to tetracycline in the intestine and prevents its absorption.; Combining potassium supplements, salt substitutes (which often contain potassium), or other drugs that increase potassium levels with ACE inhibitors may.

Etretinate

The National Institute on Drug Abuse estimates 22.7 million Americans need help treating a drug or alcohol problem. In some cases, people may take a prescription medication for pain or another. Trobicin™ (spectinomycin) For Injectable Suspension, USP. To reduce the development of drug-resistant bacteria and maintain the effectiveness of TROBICIN Sterile Powder and other antibacterial drugs, TROBICIN Sterile Powder should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria An asset with a long-term useful life that a company uses to make its products or provide its services.Strictly speaking, a fixed asset is any asset that the company does not expect to sell for at least a year, but the term often refers to assets a company expects to have indefinitely. Common examples of fixed assets are real estate and factories, which a company holds for long periods of time Dioxin is a specific organic unsaturated non-antiaromatic six-membered ring compound with a chemical formula of C4H4O2. However, the term dioxin is used generically by most authorities to include chlorinated dioxins with furans and many derivative compounds as a complex of at least 75 ubiquitous and environmentally persistent organochlorine compounds, of variable toxicity Clobetasol propionate has the molecular formula C 25 H 32 CIFO 5 and a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water. TEMOVATE® Cream contains clobetasol propionate 0.5 mg/g in a cream base of propylene glycol, glyceryl monostearate, cetostearyl alcohol, glyceryl stearate, PEG 100 stearate, white wax, chlorocresol, sodium citrate, citric acid.

The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. HIV/AIDS drug information, including FDA-approved and investigational medications General Drug Categories. Analgesics: Drugs that relieve pain. There are two main types: non-narcotic analgesics for mild pain, and narcotic analgesics for severe pain. Antacids: Drugs that relieve. Pyrazinamide should always be administered with other effective antituberculous drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Patients who are known or suspected to have drug-resistant disease should be treated with regimens individualized to their situation on May 20, 2021. Ridofranz / Getty Images. Antiretroviral drugs are used to treat HIV infection. They work by blocking a stage of the virus's life cycle and, by doing so, prevent the virus from replicating. The drugs are organized into six different classes based largely on the stage of the life cycle they inhibit

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Dangerous Drugs in Pregnancy (Teratogenic) List, Types

Teratology - Teratogenic Effects. Teratology is the study of abnormalities of physiological development. It is often thought of as the study of human congenital abnormalities, but it is broader than that, taking into account other non-birth developmental stages, including puberty; and other non-human life forms, including plants Avoid (teratogenic and toxic in animal studies. See also Pregnancy and reproductive function in Cytotoxic drugs. Breast feeding. Discontinue breast-feeding. Renal impairment. Avoid if possible—nephrotoxic. Monitoring requirements. Monitoring of patient parameters. Monitor full blood count

Online Medical Dictionary and glossary with medical definitions, d listing Internal Medicine DepartmentBoulder Medical Center. Oral hypoglycemic drugs are used only in the treatment of type 2 diabetes which is a disorder involving resistance to secreted insulin. Type 1 diabetes involves a lack of insulin and requires insulin for treatment. There are now four classes of hypoglycemic drugs: Alpha-glucosidase inhibitors Rat LD50 Oral 2600 Null Drugs of the Future., 12(944), 1987 Rat LD50 Intraperitoneal 270 Null Drugs of the Future., 12(944), 1987 Rat LD50 Intravenous 53 Null Drugs of the Future., on teratogenic risk after inadvertent exposure to Levosulpiride in early pregnancy were enrolled in this study. The women were exposed to Levosulpiride at median 4. The drug had no effect on fertility when administered in the diet to male and female rats at a daily intake of up to 4 times the recommended human dose of 1000 mg in a 50 kg individual. Pregnancy Teratogenic Effects: Pregnancy Category C Acetazolamide administere